13
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5403 | ULK-101 | Autophagy | |
ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy. | |||
T8322 | BL-918 | Autophagy | |
BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM. | |||
T8850 | Sbp-7455 | Autophagy | |
SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice. | |||
T2128 | SBI-0206965 | SBI0206965 | Apoptosis , Autophagy |
SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2. | |||
T6899 | MRT68921 | MRT68921 HCl | Autophagy |
MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. | |||
T0097 | MRT67307 | MRT67307 HCl | IκB/IKK , Autophagy |
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage... | |||
T9142 | MRT68921 dihydrochloride | Autophagy | |
MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively). | |||
T8808L | LYN-1604 dihydrochloride | LYN-1604 2HCl(2216753-86-3 free base) | Apoptosis , Autophagy |
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. | |||
T9207 | GW406108X | GW108X | Kinesin , Autophagy |
GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux. | |||
T4123 | LYN-1604 | LYN1604 | Apoptosis , Autophagy |
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. | |||
T28847 | SR-17398 | ||
SR-17398 is an inhibitor of Unc-51-Like Kinase 1 (ULK1) (IC50 = 22.4 uM). | |||
T39687 | LYN-1604 hydrochloride | ||
LYN-1604 hydrochloride, a powerful activator of UNC-51-like kinase 1 (ULK1) with an EC50 value of 18.94 nM, has significant implications in the study of triple-negative breast cancer (TNBC). | |||
T12662 | (Rac)-BL-918 | Others | |
(Rac)-BL-918 is the racemate of BL-918. BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM, inducing cytoprotective autophagy for Parkinson’s disease treatment [1]. |